BEHAVIOR OF SOLVENT-EXPOSED HYDROPHOBIC GROOVE IN THE ANTI-APOPTOTIC BCL-XL PROTEIN: CLUES FOR ITS ABILITY TO BIND DIVERSE BH3 LIGANDS FROM MD SIMULATIONS.

Bcl-XL is a member of Bcl-2 family of proteins involved in the regulation of intrinsic pathway of apoptosis.Its overexpression in many human cancers makes it an important target for anti-cancer drugs.Bcl-XL interacts with the BH3 domain of several pro-apoptotic Bcl-2 partners.This helical bundle protein has a pronounced hydrophobic groove which act

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory disorder that occurs as a consequence of immune dysregulation.HLH can be primary (familial or non-familial) or secondary to infection, autoimmune disease Nappy Bin or malignancy.Malignancy-associated HLH is often accompanied by hematologic and lymphoid neoplasms.This r

Abstract Appropriate estimation of permeability is considered as one of the significant concerns of petroleum industries.Due to the growing demand for hydrocarbon fossil fuels in numerous industries, Petroleum Engineers always try to provide holistic and sustainable solutions to measure this parameter more accurately and to calculate the proper ori

A public complaint is a reciprocal of the population against the government to convey opinions or problems encountered in certain areas.The complaint process using a suggestion box or counter complaint is less effective and efficient so that Leveling Arm the complaint handling process is slow.The geographic information system of public complaints i

DNA methylation, one of the best characterized epigenetic marks in the human genome, plays a pivotal role in gene transcription regulation and other biological processes in humans.On top of that, the DNA methylome undergoes profound changes in cancer and other disorders.However, large-scale and population-based studies are limited by high costs and